Repressor of ornithine decarboxylase. Antizyme (29 kD) is a polyamine-inducible protein involved in feedback regulation of cellular polyamine levels. The N terminus of antizyme is not required for the interaction with ODC but is necessary to induce its degradation. Antizyme can be induced by IL-1. The elaborate regulation of ODC activity in mammals still lacks a defined developmental role but an antizyme-like gene in Drosophila, gutfeeling ( guf ), is required for proper development of the embryonic peripheral nervous system.

Dictionary of molecular biology. 2004.

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  • Antizyme RNA frameshifting stimulation element — is a structural element which is found in antizyme mRNA and is known to promote frameshifting. Antizyme genes have two partially overlapping open reading frames, the second, which encodes the functional protein requires +1 translational… …   Wikipedia

  • Ornithine decarboxylase antizyme — is a ornithine decarboxylase inhibitor. It was first characterized in 1981.[1] The genes include OAZ1, OAZ2, and OAZ3. References ^ …   Wikipedia

  • AZIN1 — Antizyme inhibitor 1, also known as AZIN1, is a human gene.cite web | title = Entrez Gene: AZIN1 antizyme inhibitor 1| url = Cmd=ShowDetailView TermToSearch=51582| accessdate = ] PBB Summary… …   Wikipedia

  • OAZ1 — Ornithine decarboxylase antizyme 1 Identifiers Symbols OAZ1; AZI; MGC138338; OAZ External IDs …   Wikipedia

  • OAZ2 — Ornithine decarboxylase antizyme 2 Identifiers Symbols OAZ2; External IDs OMIM …   Wikipedia

  • ADC (gene) — Arginine decarboxylase, also known as ADC, is a human gene.cite web | title = Entrez Gene: ADC arginine decarboxylase| url = Cmd=ShowDetailView TermToSearch=113451| accessdate = ] PBB Summary… …   Wikipedia

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  • Translational frameshift — Translational frameshifting or ribosomal frameshifting refers to an alternate process of protein translation. Normally, a protein is translated from one end of the template to the other, generally from the 3 to the 5 end (or 5 to 3 ends of the… …   Wikipedia

  • ODC1 — Ornithine decarboxylase 1 PDB rendering based on 1d7k …   Wikipedia

  • agmatine — (= 1 amino 4 guanidobutane) A metabolite of arginine via arginine decarboxylase, is metabolized to putrescine by agmatinase. Suppresses polyamine biosynthesis and polyamine uptake by cells by inducing antizyme. Binds to imidazoline receptors and… …   Dictionary of molecular biology

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